GENE
SUPPLEMENTS NOT FAR OFF
Kent Fischer - 15 January 2009
Professor of molecular and cell biology at UC’s Berkeley campus, Jasper Rine predicts
consumers will be able to purchase a copy of their own human
genomes for $100 within five years.
This would provide sports supplement and functional foods manufacturers an entirely
unprecedented scope for the development of new food products - products that could be tailored to suit a particular gentic makeup to ensure maximum results
from exercise
Ready-to-buy human genomes will facilitate the development of
dietary supplements that
could patch genetic flaws in
individuals or entire populations..
ENZYMES
To transfer information, replicate,
and rejuvenate, our DNA has specific enzymes. Writing in an online early edition of the
journal, Proceeding of the National ’Academy of Sciences, Dr. Rine noted how genetic differences can reduce individual enzyme
efficiency. .
The UC Berkeley research scientists suggest that enzymatic abnormalities such as “bad copies” among our genomes were common in many
individuals. With the right information these abnormalities can be rectified with
supplementation.
These scientists suggest supplementation will play a major role in the near future to help
correct common enzymatic abnormalities in our DNA make-up.
Each person requires a different optimal dose of
nutrients, such as vitamins and minerals based on their genetic makeup and the kind of
variance they are harboring in their vitamin-dependent enzymes.
This study transplanted human gene variants into yeast cells. The scientists worked with
the human enzyme methylenetetrahydrofolatereductase (MTHFR), an
enzyme that requires folic acid to function
optimally, and is important for synthesizing molecules used to build DNA.
The scientists identified five
mutations that impaired the enzyme’s function - but for four of them, the problem was fixed by providing extra folate. Using folic acid
supplementation, full functionality was returned. The supplementation corrected a genetic flaw.
There are over 600 human enzymes that use vitamins or minerals as cofactors.
With 600 genes, we are all
likely to have some mutations that limit one or more or our
enzymes. If left untreated, these
“flaws” may develop into serious health problems. With the new information correcting
these flaws may be as simple as taking the right supplement for your genetic profile.
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